Search on: KININOGEN, HIGH-MOLECULAR-WEIGHT 
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Descriptor English:   Kininogen, High-Molecular-Weight 
Descriptor Spanish:   Quininógeno de Alto Peso Molecular 
Descriptor Portuguese:   Cininogênio de Alto Peso Molecular 
Synonyms English:   High-Molecular-Weight Kininogen  
Tree Number:   D12.644.276.812.654.350
D12.776.124.125.635.480
D12.776.467.812.654.350
D12.776.811.420.350
D23.119.630.480
D23.469.050.375.425.350
D23.529.812.654.350
Definition English:   A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed) 
Indexing Annotation English:   DF: HMWK
History Note English:   98; use KININOGENS 1989-97 
Allowable Qualifiers English:  
administration & dosage adverse effects
agonists antagonists & inhibitors
analysis biosynthesis
blood cerebrospinal fluid
chemistry classification
chemical synthesis contraindications
deficiency diagnostic use
economics genetics
history immunology
isolation & purification metabolism
pharmacology physiology
pharmacokinetics poisoning
radiation effects supply & distribution
secretion standards
toxicity therapeutic use
urine  
Record Number:   33486 
Unique Identifier:   D019679 

Occurrence in VHL: 		 

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